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Menebar Ilmu Pengetahuan

Iron deficiency anemia (IDA): Mari Mutakhirkan Pengetahuan dengan 22 pustaka ini

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IDA bisa terjadi setelah kehilangan darah dalam jumlah besar atau tidak cukupnya intake/asupan zat besi dan absorpsi, mengakibatkan tidak cukupnya simpanan zat besi selama perkembangan sel darah merah. Zat besi berperan sebagai kofaktor dari protein hemoglobin, yang penting dalam pengangkutan oksigen ke seluruh tubuh.

Defisiensi besi adalah defisiensi nutrisi paling umum di seluruh dunia. Untuk pencegahan IDA, pertimbangkan suplementasi zat besi selama kehamilan dengan 30 mg /hari mulai kunjungan prenatal pertama (rekomendasi lemah). Pasien kemungkinan asimptomatik namun dengan kondisi fatigue, dyspnea, pica, dan gejala tidak spesifik lainnya kemungkinan sedang mengalami anemia yang lebih parah.Manajemen

  1. Obati penyebab IDA misal gangguan menstrual, celiac disease, peptic ulcer disease, inflammatory bowel disease, medications, Helicobacter pylori, Whipple disease dan infeksi lainnya, diverticulosis, dan kanker kolorektal.
  2. Memberikan suplementasi zat besi 60-120 mg/hari oral zat besi dan menilai kembali tingkat hemoglobin di sekitar 3 minggu. Lanjutkan suplementasi zat besi selama kurang lebih 6 bulan pada pasien dengan IDA parah.
  3. Formulasi controlled-release dan polysaccharide-iron complex mungkin memiliki lebih sedikit efek samping pada gastrointestinal dari sediaan besi sulfat.
  4. Sediaan besi IV diindikasikan untuk pasien tidak setuju untuk terapi oral, tetapi besi dekstran IV mungkin berhubungan dengan reaksi anafilaksis yang mengancam jiwa (segera atau tertunda).
  5. Melakukan transfusi darah pada kehilangan darah akut, hemoglobin <7 g / dL (<10 g / dL untuk gejala parah penyakit kardiorespirasi), dan kehilangan darah yang sedang berlangsung (rekomendasi kuat).
  6. Meningkatkan asupan besi pada pasien dan mempertimbangkan penambahan asam askorbat (vitamin C) untuk meningkatkan penyerapan zat besi.

Nah ini dia, paper-paper yang sangat kaya dengan informasi:

International guidelines

1. World Health Organization (WHO) guideline on intermittent iron and folic acid supplementation in menstruating women can be found athttp://www.who.int/…/guideline_iron_folicacid_suppl_wom…/en/

2. international expert recommendation on diagnosis and treatment of iron deficiency anemia during pregnancy and postpartum period in Asia-Pacific region can be found in http://www.ncbi.nlm.nih.gov/pubmed/21070128?dopt=Abstract

Review articles

1. review can be found in NEJMhttp://www.ncbi.nlm.nih.gov/pubmed/25946282?dopt=Abstract

2. review can be found in http://www.ncbi.nlm.nih.gov/pubmed/18954837?dopt=Abstract

3. brief review can be found in BMJhttp://www.ncbi.nlm.nih.gov/pubmed/17272570?dopt=Abstract

4. review can be found in http://www.ncbi.nlm.nih.gov/pubmed/15737893?dopt=Abstract

5. review of guidelines on diagnosis and treatment of iron deficiency across indications can be found inhttp://www.ncbi.nlm.nih.gov/pubmed/26561626?dopt=Abstract

6. review of microcytic anemias can be found in NEJMhttp://www.ncbi.nlm.nih.gov/pubmed/25271605?dopt=Abstract

7. review of evaluation and management can be found inhttp://www.ncbi.nlm.nih.gov/pubmed/23317073?dopt=Abstract

8. review of diagnosis and management can be found inhttp://www.ncbi.nlm.nih.gov/pubmed/19262200?dopt=Abstract

9. review of functional iron deficiency diagnosis can be found inhttp://www.ncbi.nlm.nih.gov/pubmed/23573815?dopt=Abstract

10. AHRQ comparative effectiveness review on biomarkers for assessing and managing iron deficiency anemia in late-stage chronic kidney disease can be found at http://effectivehealthcare.ahrq.gov/search-for-guides-rev…/…

11. review of nutritional iron deficiency can be found in Lancethttp://www.ncbi.nlm.nih.gov/pubmed/17693180?dopt=Abstract

12. review of evaluation of microcytosis can be found in Am Fam Physician http://www.ncbi.nlm.nih.gov/pubmed/21121557?dopt=Abstract13,

13. review of IV iron in anemia can be found in Lancethttp://www.ncbi.nlm.nih.gov/pubmed/17482969?dopt=Abstract

14. review of management of common forms of anemia can be found in Am Fam Physician http://www.ncbi.nlm.nih.gov/pubmed/10193599?dopt=Abstract

15. review of anemia in older persons can be found in Am Fam Physicianhttp://www.ncbi.nlm.nih.gov/pubmed/20822082?dopt=Abstract

16. review of anemia in the elderly can be found in Mayo Clin Prochttp://www.ncbi.nlm.nih.gov/pubmed/17673065?dopt=Abstract

17. review of anemia in the elderly can be found in Am Fam Physicianhttp://www.ncbi.nlm.nih.gov/pubmed/11037074?dopt=Abstract

18. review of disorders of iron metabolism can be found in N Engl J Medhttp://www.ncbi.nlm.nih.gov/pubmed/10607817?dopt=Abstract

19. review of oral manifestations of systemic disease can be found in Am Fam Physician http://www.ncbi.nlm.nih.gov/pubmed/21121523?dopt=Abstract

20. review of anemia in low-income and middle-income countries can be found in Lancet http://www.ncbi.nlm.nih.gov/pubmed/21813172?dopt=Abstract

Referensi:

DynaMed Plus [Internet]. Ipswich (MA): EBSCO Information Services. 1995 – . Record No. 115986, Iron deficiency anemia in adults; [updated 2015 Dec 28, cited Jan 11, 2016]; [about 27 screens]. Available fromhttp://www.dynamed.com/login.aspx…. Registration and login required.

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menebar ilmu pengetahuan

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