Metastases are responsible for the majority of cancer fatalities. The molecular mechanisms governing metastasis are poorly understood, hindering early diagnosis and treatment. Previous studies of gene expression patterns in metastasis have concentrated on selection of a small number of “signature” biomarkers.
Andrey A Ptitsyn, Michael M Weil, Douglas H Thamm, Systems biology approach to identification of biomarkers for metastatic progression in cancer, Proceedings of the Fifth Annual MCBIOS Conference. Systems Biology: Bridging the Omics, 2008 [link]