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Menebar Ilmu Pengetahuan

Global Systems Biology

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Metabolic conversions under direct host cell genome/proteome control or under mitochondrial control, for example, all major energy-generating pathways and biosynthetic routes.


The measurement of metabolite concentrations and fluxes and secretions in cells and tissues in which there is a direct connection between the genetic activity (gene expression), protein activity (proteome) and the metabolic activity itself.


The full set of metabolites within, or that can be secreted by, a given cell type of tissue.


The quantitative measurement of the multivariate metabolic responses of multicellular systems to pathophysiological stimuli or genetic modification. An approach to understanding global metabolic regulation of organism and its commensal and symbiotic partners.


The sum of the cellular metabolomes in a multicellular organism and their interaction components plus the products of facile chemical transformations and extra-genomically generated metabolites.


A compound that is produced by a facile chemical rearrangement or reaction within an organism, that can be excreted or further metabolized.


Processes or compounds that are essential to host biological function and which can be metabolized or further utilized by host, but for which there is no biosynthetic  capability in the host genome, for example, vitamins and essential amino acids.


Metabolites or processes involving co-metabolism by two or more organisms that are commensal or symbiotic (for example, bile acid metabolism). Not necessarily essential to the host, but can influence endogenous or other xenobiotic metabolic processes.


Compounds of extra-genomic or chemical origin but which are metabolically converted to endogenous species or metabolites that can be utilized directly in endogenous processes, for example, ethanol.


A compound that is foreign to the endogenous process and has no intrinsic biological function but which can have major effects on endogenous pathway control and can be extensively metabolized by complexes of host enzymic systems that have collectively relatively low substrate specificities.


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menebar ilmu pengetahuan

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